Effects of rHu-EPO in Different Dose on Brain Injury of Premature Infants / 医学研究杂志

ABSTRACT

Objective To study the effects and side effects of different dose of rHu-EPO on the treatment of brain injury in premature infants. Methods The infants who had suffered fetal distress and first one minute of Apgar was under 7score after birth and were sent to NICU within 24h were studied. We totally collected 90 infants and divided into three groups randomly, including large dose group, small dose group and control group. The large and small group were injected hypodermicly with rHu-EPO 1000U/kg, 500U/kg, three times per week for three weeks, and the control group were given general treatment without rHu-EPO at same time. Before treatment, one week and three weeks after treatment, we collected concentration of NSE, S100B and skull ultrasound to assess the effects. Neonatal behavioral neurological assessment(NBNA) were performed twice before and at weeks of correct gestational age. To survey the side effects, we collected general information such as the incidence rate of ROP and hemangioma, AST/ALT/PLT/Urea /Cr and so on. Results After one-week treatment, the concentration of NSE and S100B were no significant difference(P ＞ 0. 05) in the small dose group, but were statistically significant in the large dose group(P ＜ 0. 05). After three-week treatment, the comparison of NSE、S100B in both groups was statistically significant(P ＜ 0. 05). The head ultrasound comparison was of statistically significant in both group(P ＜ 0. 05), and so as NBNA and head MRI. The frequency of blood transfusion was statistically significant in both group(P ＜ 0. 05) compared with control group. Routine blood test including liver and kidney function showed that there was no significant difference before and after treatment(P ＞ 0. 05). Conclusion The neuroprotective effect of rHu-EPO on brain injury in preterm infants is connected with its dose and period of treatment, it need high dose or long time to express neuroprotective function.