An association between single nucleotide polymorphisms of IL-23R gene and Keshan disease in Northwest Chinese Han population / 中华地方病学杂志
Chinese Journal of Endemiology
;
(12): 357-360, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-753503
ABSTRACT
Objective To investigate the relationship between single nucleotide polymorphisms of interleukin 23 receptor (IL-23R) gene and Keshan disease (KD) in Northwest Chinese Han population.Methods A total of 285 Chinese Han subjects from Huangling,Shaanxi,including 79 KD patients (case group) and 206 control subjects (control group) were involved in this study.Genomic DNA was extracted from peripheral venous blood.The polymorphism of genetic variation was genotyped by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF).All sample groups were tested for Hardy-Weinberg equilibrium using goodness-of-fit x2 test.Differences in genotype distribution between two groups were compared by x2 test.Logistic regression analysis was applied to detect association using age as a confounding factor.Results The gene frequency distribution of IL-23R gene rs10889677 in case group and control group conformed to the Hardy-Weinberg equilibrium (x2 =0.254,P > 0.05).Correlation analysis results:
the difference of genotype frequency of IL-23R gene rs10889677 in case group (CC,CA,AA were 6.3%,36.7%,57.0%,respectively) and control group (CC,CA,AA were 5.3%,43.2%,51.5%,respectively) was not statistically significant (x2 =1.008,P > 0.05).After age adjustment,there was no significant difference in genotype frequency of IL-23R gene rs10889677 (x2sdj =0.669,P > 0.05) between two groups.Conclusion There is no correlation between IL-23R gene rs10889677 and KD in Northwest Chinese Han population.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Endemiology
Ano de publicação:
2019
Tipo de documento:
Artigo
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