Retrospective analysis of epidemiological characteristics and clinical features of patients with acute brucellosis in Hulunbuir of Inner Mongolia / 中华地方病学杂志

ABSTRACT

Objective To analyze the epidemiological and clinical characteristics of patients with acute brucellosis for providing theoretical basis for its clinical diagnosis and treatment in Hulunbuir of Inner Mongolia.Methods The epidemiology,clinical features,laboratory examination and therapeutic effect of acute brucellosis patients admitted to Department of Brucellosis of Hulunbuir People's Hospital from January 2013 to December 2017 were retrospectively evaluated.Results Totally there were 197 patients with acute brucellosis were collected,139 males and 58 females aged from 19 to 71 years old (average age 39.2).There were 179 cases with a clear history of epidemiology,and 168 cases had directly contacted with animals,39 cases had family history of brucellosis.The dominant manifestations were fever in 181 cases (91.9％),sweats in 159 cases (80.7％),and the dominant sign was splenomegaly in 28 cases (14.2％).There were 123 cases (62.4％) with complications,most patients with osteoarticular involvement and liver damage,43 and 59 cases (21.8％ and 29.9％) respectively.Both the Rose Bengal Plate Agglutination Test (RBPT) and Standard Tube Agglutination Test (SAT) were positive in 197 patients,the blood culture was positive in only 37 cases.Cerebrospinal fluid SAT positive was in 8 cases,and pleural effusion SAT in 2 cases;cerebrospinal fluid and pleural effusion culture were negative.Of the 197 patients,185 patients had a good effect after treatment,and the treatment effective rate was 93.9％.Conclusions Acute brucellosis is an infection with multiple presentations,the presence of persistent fever,sweats,muscular soreness and arthralgia should alert clinicians the possibility of acute brucellosis.Early diagnosis and treatment will reduce the incidence of complications.