Semi-quantitative analysis of the effect of 131I on residual thyroid tissue in patients with differentiated thyroid cancer / 中华地方病学杂志

ABSTRACT

Objective To evaluate the effect of postoperative thyroid residual tissue on 131I treatment of differentiated thyroid carcinoma (DTC) metastases in patients with DTC.Methods Patients with thyroid residual tissue and lymph node metastases or distant organ metastases were confirmed by 131I whole body scan after 131I treatment of DTC from January 2004 to January 2013 in Dalian.The clinical data were divided into the cured group and the non-cured group according to the final results of mI treatment.The per unit area count value (Kc/cm2) of residual thyroid remnant (NTR),lymph node metastases (LNM) and distant metastases (DM) were measured and performed semi-quantitative analysis.The thresholds of the analysis results were calculated by the Bootstrap method.Results A total of 114 patients were studied,aged from 14 to 80 years old,including 47 males and 67 females;the ratio of males to females was 1.01.4.There were significant differences in NTR unit area counts (0.25 vs 1.29 Kc/cm2) between the cured group and the non-cured group (72 in the cured group and 42 in the non-cured group,U =0.001,P ＜ 0.05);there was no significant difference in LNM unit area counts (0.21 vs 0.41 Kc/cm2) between the cured group and the non-cured group (U =0.052,P ＞ 0.05).Those with the ratio of residual area to lymph node metastases (N/L) and the ratio of residual area to distant metastases(N/D) less than 1.7 had a better 131I treatment;unit area N/L greater than 4.9 and unit area N/D greater than 8.0 had a poor therapeutic effect.Conclusion Excessive residual tissue after surgery results in poor efficacy of 131I treatment;semi-quantitative analysis for whole body scan after 131I treatment can predict the efficacy of 131I treatment.