Analysis of pathogen distribution and drug resistance of pediatric purulent meningitis / 中国基层医药

ABSTRACT

To explore the bacteriological characteristics and bacterial resistance of children with purulent meningitis in the Shenmu Hospital ,and to provide evidence for the rational use of antibiotics.Methods We retrospectively analyzed the clinical data and bacterial culture results of 43 children with purulent meningitis in our hospital from June 2009 to March 2017.Results There were 21 types of bacteria culture and drug susceptibility testGram-positive bacteria in 16 cases (76.19%), Gram negative bacilli in 5 cases (23.81%), including 8 staph infections,gambogic／lira micrococcus in 4 cases, excrement enterococcus in 1 case, streptococcus pneumoniae in 2 cases,produce mononuclear listeria in 1 case.All the Gram-negative bacilli were Escherichia coli.In cerebrospinal fluid culture,Gram-positive bacteria were significantly higher than Gram -negative bacteria,and the difference was statistically significant(χ2 ＝7.813,P ＝0.005).There was no statistically significant difference in the number of Gram-positive cases between cerebrospinal fluid and blood culture pathogens (χ2 ＝0.075,P＝0.78).Gram positive coccus was generally resistant to penicillin , erythromycin and clindamycin , generation 1 cephalosporin antibiotic , including pneumococcal resistance rate was 100.0%,coagulase negative staphylococcus resistance rate was 87.5%, E.coli was resistant to ampicillin and levofloxacin.Conclusion In the pediatric treatment of our hospital ,coagulase negative staphylococcus aureus and vine／Lila micrococcus is the important pathogenic bacteria that causes the children purulent meningitis, Escherichia coli is the only pathogenic bacteria of the Gram -negative bacterial meningitis. Vancomycin and linezolide are sensitive to cocci ,and Escherichia coli is sensitive to antibiotics in the second and third generation of cephalosporins.