Relationship between apolipoprotein E genepolymorphism and cerebrovascular disease in Tibetan people in Qinghai province / 中国神经精神疾病杂志

ABSTRACT

Objective To discuss the correlation of apolipoprotein E (ApoE) gene polymorphism with cerebral infarction (CI)and intracerebral hemorrhage (ICH) among Tibetan nationality with cerebrovascular diseases in Qinghai Province, seek the differences in each allele of ApoE in Tibetan nationality. Methods The data from a total of 94 patients with cerebrovascular diseases was collected from the people's hospital of qinghai province, the people's hospital of guoluo prefecture , and the people's hospital of yushu prefecture as the cerebrovascular disease group, including 48 cases of cerebral infarction. There were 46 cases of cerebral hemorrhage. A total of 96 healthy Tibetan subjects were selected as the control group. DNA was extracted from all subjects. Real－time PCR was used to detect ApoE. The correlation between ApoE genotype and cerebral infarction and cerebral hemorrhage was analyzed. Results E2/E3 gene was common in Tibetan nationality with cerebrovascular diseases. E2/E3 genotype accounted for 50% in cerebral infarction group. E2/E3 (65.2%) was the most common in intracerebral hemorrhage group. E2/E4 (64.6%) was the most common in the control group. There was a statistically significant difference between the two groups (P＜0.01). In the Tibetan population, ε3 allele genome (48.0%) was the most common in cerebral infarction group and ε2(43.5%) were the most common alleles in intracerebral hemorrhage group. In the normal control group, ε4 (49.0%) was the most common allele. Conclusion E2/E3 genotype may be related to cerebrovascular diseases. ε3 allele may be the susceptible factor of cerebral infarction wherase ε4 may be the protective factor of cerebrovascular diseases in Tibetan population.