Relationship between Vimentin Expression and Progression of Uterine Cervix Epithelial Neoplasms
Korean Journal of Pathology
;
: 663-669, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-75503
ABSTRACT
Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but the evidence of the aberrant expression of vimentin in epithelial cancer cells suggests that the vimentin expression might be related to local invasiveness and metastatic potential. There have been a few previous studies on the vimentin expression in human cervical carcinogenesis using in vivo and in vitro models. We examined the immunohistochemical vimentin expression in various squamous epithelial neoplasms of the uterine cervix, including the cervical intraepithelial neoplasia group (n=25), the microinvasive squamous cell carcinoma group (n=15), the invasive squamous cell carcinoma group (n=15) and the metastatic squamous cell carcinoma group (n=8). Vimentin positivity was significantly higher in the invasive than in the intraepithelial group, and in the cases with lymph node metastasis than in those without metastasis, suggesting a relationship between the vimentin expression and progression of the uterine cervical epithelial tumors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vimentina
/
Filamentos Intermediários
/
Carcinoma de Células Escamosas
/
Displasia do Colo do Útero
/
Colo do Útero
/
Neoplasias Epiteliais e Glandulares
/
Carcinogênese
/
Linfonodos
/
Metástase Neoplásica
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pathology
Ano de publicação:
1998
Tipo de documento:
Artigo
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