Research progress of the relationship between chronic inflammation and pancreatic ductal adenocarcinoma / 中华肝胆外科杂志

ABSTRACT

Studies have demonstrated a strong correlation between chronic inflammation and tumor initiation and progression.Chronic intlammation is mainly involved in tumor progression through intrinsic and extrinsic pathways,and transcription factors such as NF-κB and STAT3 play important roles.Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies.Chronic inflammation can promote the development of PDAC in cooperation with mutation of protooncogene.Inflammation signaling pathway plays an important role in malignant transformation in the PDAC,in which NF-κB and STAT3 are two major transcription factors.Targeting the key regulator points based on the crosstalk between inflammation signaling and PDAC may potentially represent a novel for PDAC prevention and treatment.This article briefly reviews the role of chronic inflammation in the development of PDAC,the PDAC-related inflammatory signal network caused by chronic inflammation,and crosstalk between NF-κB and JAK/STAT3 signaling pathways.