Application of lung V/Q SPECT imaging in fibrosing mediastinitis / 中华核医学与分子影像杂志

ABSTRACT

Objective To investigate the value of pulmonary ventilation/perfusion (V/Q) SPECT imaging in fibrosing mediastinitis (FM).Methods From January 2015 to July 2018,14 FM patients (6 males,8 females,average age 74 years) who underwent V/Q SPECT imaging in China-Japan Friendship Hospital were retrospectively studied.The data of V/Q SPECT imaging were analyzed and the defect extent was classified as mild (＜20％),moderate (20％-50％) and severe (＞50％) according to the percentage of pulmonary perfusion and ventilation defect in total lung volume (％).x2 test was used to analyze the incidence rates of the impaired blood perfusion of each lung lobe.Results According to the results of Q SPECT imaging,all 14 patients had impaired blood perfusion in the superior lobe of left lung,and the number of patients with/without impaired blood perfusion in the inferior lobe of left lung,superior lobe of right lung,middle lobe of right lung,inferior lobe of right lung were 11/3,14/0,13/1,12/2,respectively.The incidence rates of impaired blood perfusion in different lobes were not significantly different (x2=6.198,P=0.185).The range of lung perfusion defect was mild in 1,moderate in 7 and severe in 6 patients.The incidence rates of impaired blood ventilation in different lobes were not significantly different (x2 =1.587,P=0.811).The range of lung ventilation defeat was mild in 11,moderate in 2 and severe in 1 patients.The defect extent of lung segments and subsegments in Q SPECT imaging and V SPECT imaging were 119 and 41,respectively (x2=28.42,P＜0.05).There was more defect in Q SPECT imaging,but both methods showed segmental or subsegmental distribution.Conclusions The defect of V/Q SPECT imaging in FM patients is segmental in distribution,and more is observed in Q SPECT imaging.Pulmonary V/Q SPECT imaging can evaluate the defect range and extent of pulmonary perfusion and ventilation in FM patients.