The clinical significance of interferon inducible protein-10 in patients having chronic hepatitis C with genotype I / 대한내과학회지
Korean Journal of Medicine
;
: 652-660, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-75594
ABSTRACT
BACKGROUND/AIMS:
Recent studies have shown that serum interferon gamma-inducible protein-10 (IP-10) concentration decreased after pegylated interferon and ribavirin therapy, and was associated with a sustained virologic response (SVR). The aim of this study was to investigate the clinical significance of the pretreatment IP-10 level and change in serum IP-10 level between 1 month before and after treatment and its association with various virologic responses in patients having chronic hepatitis C (CHC) with genotype 1 undergoing pegylated interferon and ribavirin therapy.METHODS:
Thirty-six patients having CHC with genotype I undergoing pegylated interferon and ribavirin therapy who had available stored sera 1 month before and after treatment were enrolled retrospectively. Serum IP-10 levels were measured by ELISA. Serum HCV RNA was measured by RT-PCR (detection limit0.05). The change in serum IP-10 between 1 month before and after treatment had no clinical meaning based on various virologic responses (p>0.05).CONCLUSIONS:
The level of pretreatment IP-10 and change in IP-10 level between 1 month before and after treatment were not predictive factors of a SVR. Additional large-scale studies to determine the SVR-predicting role of serum IP-10 levels in patients with CHC are needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ribavirina
/
RNA
/
Ensaio de Imunoadsorção Enzimática
/
Estudos Retrospectivos
/
Interferons
/
Hepatite C Crônica
/
Genótipo
/
Hepatite Crônica
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2010
Tipo de documento:
Artigo
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