Your browser doesn't support javascript.
loading
Potential coordination role between O-GlcNAcylation and epigenetics
Protein & Cell ; (12): 713-723, 2017.
Artigo em Inglês | WPRIM | ID: wpr-756979
ABSTRACT
Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine (Ser) and threonine (Thr) residues of the specific substrate proteins via the addition of O-GlcNAc group by OGT. It has been known that O-GlcNAcylation is not only involved in many fundamental cellular processes, but also plays an important role in cancer development through various mechanisms. Recently, accumulating data reveal that O-GlcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GlcNAcylation as 'protein code' or 'histone code' may provide recognition platforms or executive instructions for subsequent recruitment of proteins to carry out the specific functions. In this review, we summarize the interaction of O-GlcNAcylation and epigenetic changes, introduce recent research findings that link crosstalk between O-GlcNAcylation and epigenetic changes, and speculate on the potential coordination role of O-GlcNAcylation with epigenetic changes in intracellular biological processes.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acetilglucosamina / Processamento de Proteína Pós-Traducional / N-Acetilglucosaminiltransferases / Epigênese Genética / Genética / Glicosídeo Hidrolases / Metabolismo / Neoplasias Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2017 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acetilglucosamina / Processamento de Proteína Pós-Traducional / N-Acetilglucosaminiltransferases / Epigênese Genética / Genética / Glicosídeo Hidrolases / Metabolismo / Neoplasias Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2017 Tipo de documento: Artigo