Increasing the safety and efficacy of chimeric antigen receptor T cell therapy
Protein & Cell
; (12): 573-589, 2017.
Article
em En
| WPRIM
| ID: wpr-756986
Biblioteca responsável:
WPRO
ABSTRACT
Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has recently been undergoing rapid development. However, there are still some major challenges, including precise tumor targeting to avoid off-target or "on-target/off-tumor" toxicity, adequate T cell infiltration and migration to solid tumors and T cell proliferation and persistence across the physical and biochemical barriers of solid tumors. In this review, we focus on the primary challenges and strategies to design safe and effective CAR T cells, including using novel cutting-edge technologies for CAR and vector designs to increase both the safety and efficacy, further T cell modification to overcome the tumor-associated immune suppression, and using gene editing technologies to generate universal CAR T cells. All these efforts promote the development and evolution of CAR T cell therapy and move toward our ultimate goal-curing cancer with high safety, high efficacy, and low cost.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Terapêutica
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Transplante
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Proteínas Recombinantes de Fusão
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Ativação Linfocitária
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Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Transdução de Sinais
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Expressão Gênica
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Movimento Celular
Limite:
Humans
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2017
Tipo de documento:
Article