Molecular regulation of telomerase activity in aging
Protein & Cell
;
(12): 726-738, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-757047
ABSTRACT
The process of aging is mitigated by the maintenance and repair of chromosome ends (telomeres), resulting in extended lifespan. This review examines the molecular mechanisms underlying the actions and regulation of the enzyme telomerase reverse transcriptase (TERT), which functions as the primary mechanism of telomere maintenance and regulates cellular life expectancy. Underpinning increased cell proliferation, telomerase is also a key factor in facilitating cancer cell immortalization. The review focuses on aspects of hormonal regulations of telomerase, and the intracellular pathways that converge to regulate telomerase activity with an emphasis on molecular interactions at protein and gene levels. In addition, the basic structure and function of two key telomerase enzyme components-the catalytic subunit TERT and the template RNA (TERC) are discussed briefly.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Envelhecimento
/
RNA
/
Sequência de Bases
/
Transdução de Sinais
/
Regulação Enzimológica da Expressão Gênica
/
Fator de Transcrição Sp1
/
Regiões Promotoras Genéticas
/
Telômero
/
Dobramento de Proteína
/
Processamento Alternativo
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2011
Tipo de documento:
Artigo
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