Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention
Protein & Cell
;
(12): 691-695, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-757051
ABSTRACT
Biotin is an important micronutrient that serves as an essential enzyme cofactor. Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources. Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis. Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria. Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth, infection and survival during the latency phase. These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Virulência
/
Biotina
/
Estrutura Molecular
/
Proteínas de Transporte
/
Membrana Celular
/
Genoma Bacteriano
/
Coenzimas
/
Carbono-Carbono Ligases
/
Redes e Vias Metabólicas
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2011
Tipo de documento:
Artigo
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