Silencing suppressors: viral weapons for countering host cell defenses
Protein & Cell
;
(12): 273-281, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-757098
ABSTRACT
RNA silencing is a conserved eukaryotic pathway involved in the suppression of gene expression via sequence-specific interactions that are mediated by 21-23 nt RNA molecules. During infection, RNAi can act as an innate immune system to defend against viruses. As a counter-defensive strategy, silencing suppressors are encoded by viruses to inhibit various stages of the silencing process. These suppressors are diverse in sequence and structure and act via different mechanisms. In this review, we discuss whether RNAi is a defensive strategy in mammalian host cells and whether silencing suppressors can be encoded by mammalian viruses. We also review the modes of action proposed for some silencing suppressors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Vírus de Plantas
/
Plantas
/
Proteínas Repressoras
/
Proteínas Virais
/
Virologia
/
Vírus
/
Regulação Viral da Expressão Gênica
/
Inativação Gênica
/
MicroRNAs
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2011
Tipo de documento:
Artigo
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