Thermodynamics of ABC transporters
Protein & Cell
;
(12): 17-27, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-757179
ABSTRACT
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Termodinâmica
/
Trifosfato de Adenosina
/
Transportadores de Cassetes de Ligação de ATP
/
Metabolismo
/
Modelos Teóricos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2016
Tipo de documento:
Artigo
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