Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling
Protein & Cell
;
(12): 762-768, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757223
ABSTRACT
We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic β-catenin accumulation. β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation. Overall, our findings suggest that suppression of GSK3β by ERK stimulates β-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Transcrição Gênica
/
Transdução de Sinais
/
Regulação Enzimológica da Expressão Gênica
/
Linhagem Celular
/
Movimento Celular
/
Lipopolissacarídeos
/
Metaloproteinase 9 da Matriz
/
Biologia Celular
/
Quinase 3 da Glicogênio Sintase
Limite:
Animais
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS