Mitochondria in the pathogenesis of diabetes: a proteomic view
Protein & Cell
;
(12): 648-660, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757252
ABSTRACT
Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia due to absolute or relative lack of insulin. Though great efforts have been made to investigate the pathogenesis of diabetes, the underlying mechanism behind the development of diabetes and its complications remains unexplored. Cumulative evidence has linked mitochondrial modification to the pathogenesis of diabetes and its complications and they are also observed in various tissues affected by diabetes. Proteomics is an attractive tool for the study of diabetes since it allows researchers to compare normal and diabetic samples by identifying and quantifying the differentially expressed proteins in tissues, cells or organelles. Great progress has already been made in mitochondrial proteomics to elucidate the role of mitochondria in the pathogenesis of diabetes and its complications. Further studies on the changes of mitochondrial protein specifically post-translational modifications during the diabetic state using proteomic tools, would provide more information to better understand diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Tecido Adiposo
/
Músculo Esquelético
/
Proteoma
/
Biologia Celular
/
Proteômica
/
Complicações do Diabetes
/
Diabetes Mellitus
/
Células Secretoras de Insulina
/
Insulina
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS