The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1
Protein & Cell
;
(12): 372-382, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757269
ABSTRACT
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Virologia
/
Leucemia Promielocítica Aguda
/
Latência Viral
/
Proteínas Imediatamente Precoces
/
Herpesvirus Humano 1
/
Corpos de Inclusão Intranuclear
/
Ubiquitina-Proteína Ligases
/
Genética
/
Herpes Simples
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
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