Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
Protein & Cell
;
(12): 173-181, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757284
ABSTRACT
Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis. Lipid homeostasis, especially cholesterol homeostasis, plays a crucial role during the formation of foam cells. Recently, lipid droplet-associated proteins, including PAT and CIDE family proteins, have been shown to control the development of atherosclerosis by regulating the formation, growth, stabilization and functions of lipid droplets in macrophage-derived foam cells. This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins. Understanding the process of foam cell formation will aid in the future discovery of novel therapeutic interventions for atherosclerosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Aciltransferases
/
Colesterol
/
Biologia Celular
/
Receptores Ativados por Proliferador de Peroxissomo
/
Alergia e Imunologia
/
Aterosclerose
/
Proteínas Reguladoras de Apoptose
/
Proteínas de Ligação a Elemento Regulador de Esterol
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
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