Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy
Protein & Cell
;
(12): 246-250, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757286
ABSTRACT
Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Transplante
/
Diferenciação Celular
/
Hepatócitos
/
Biologia Celular
/
Avaliação Pré-Clínica de Medicamentos
/
Células-Tronco Pluripotentes Induzidas
/
Terapia Baseada em Transplante de Células e Tecidos
/
Hepatopatias
/
Modelos Biológicos
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
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