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Converted neural cells: induced to a cure?
Protein & Cell ; (12): 91-97, 2012.
Article em En | WPRIM | ID: wpr-757295
Biblioteca responsável: WPRO
ABSTRACT
Many neurodegenerative disorders such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many groups were able to generate neural cells, either differentiated from induced pluripotent stem cells (iPSCs) or converted from somatic cells. Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs. In addition, the converted neural cells also hold the promise for cell replacement therapy (Kikuchi et al., 2011; Krencik et al., 2011; Kriks et al., 2011; Nori et al., 2011; Rhee et al., 2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Doença de Parkinson / Terapêutica / Transplante / Acidente Vascular Cerebral / Biologia Celular / Transdiferenciação Celular / Células-Tronco Pluripotentes Induzidas / Terapia Baseada em Transplante de Células e Tecidos / Esclerose Lateral Amiotrófica / Neurônios Limite: Animals Idioma: En Revista: Protein & Cell Ano de publicação: 2012 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Doença de Parkinson / Terapêutica / Transplante / Acidente Vascular Cerebral / Biologia Celular / Transdiferenciação Celular / Células-Tronco Pluripotentes Induzidas / Terapia Baseada em Transplante de Células e Tecidos / Esclerose Lateral Amiotrófica / Neurônios Limite: Animals Idioma: En Revista: Protein & Cell Ano de publicação: 2012 Tipo de documento: Article