Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
Protein & Cell
;
(12): 4-13, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-757375
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Genômica
/
Proteômica
/
Metabolismo dos Lipídeos
/
Estudo de Associação Genômica Ampla
/
Gotículas Lipídicas
/
Hepatopatia Gordurosa não Alcoólica
/
Genética
/
17-Hidroxiesteroide Desidrogenases
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2017
Tipo de documento:
Artigo
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