Heteromerization of TRP channel subunits: extending functional diversity
Protein & Cell
;
(12): 802-810, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-757438
ABSTRACT
Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Modelos Moleculares
/
Química
/
Estrutura Terciária de Proteína
/
Repetição de Anquirina
/
Estrutura Quaternária de Proteína
/
Subunidades Proteicas
/
Canais de Cátion TRPC
/
Domínios e Motivos de Interação entre Proteínas
/
Multimerização Proteica
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2010
Tipo de documento:
Artigo
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