Cilia in cell signaling and human disorders
Protein & Cell
; (12): 726-736, 2010.
Article
em En
| WPRIM
| ID: wpr-757446
Biblioteca responsável:
WPRO
ABSTRACT
One of the most widespread cellular organelles in nature is cilium, which is found in many unicellular and multicellular organisms. Formerly thought to be a mostly vestigial organelle, the cilium has been discovered in the past several decades to play critical motile and sensory roles involved in normal organogenesis during development. The role of cilia has also been implicated in an ever increasing array of seemingly unrelated human diseases, including blindness, kidney cysts, neural tube defects and obesity. In this article we review some of the recent developments in research on cilia, and how defects in ciliogenesis and function can give rise to developmental disorders and disease.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Fisiologia
/
Anormalidades Múltiplas
/
Transdução de Sinais
/
Doenças Cerebelares
/
Cílios
/
Modelos Animais
/
Transporte Proteico
/
Proteínas Wnt
/
Proteínas Hedgehog
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2010
Tipo de documento:
Article