Mutual regulation between Hippo signaling and actin cytoskeleton
Protein & Cell
;
(12): 904-910, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-757544
ABSTRACT
Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfoproteínas
/
Fosforilação
/
Fisiologia
/
Fatores de Transcrição
/
Citoesqueleto de Actina
/
Proteínas Nucleares
/
Transdução de Sinais
/
Transativadores
/
Regulação da Expressão Gênica
/
Proteínas Serina-Treonina Quinases
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2013
Tipo de documento:
Artigo
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