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MicroRNA-21 in the pathogenesis of acute kidney injury
Protein & Cell ; (12): 813-819, 2013.
Artigo em Inglês | WPRIM | ID: wpr-757548
ABSTRACT
Acute kidney injury (AKI), associated with significant morbidity and mortality, is widely known to involve epithelial apoptosis, excessive inflammation, and fibrosis in response to ischemia or reperfusion injury, which results in either chronic pathological changes or death. Therefore, it is imperative that investigations are conducted in order to find effective, early diagnoses, and therapeutic targets needed to help prevent and treat AKI. However, the mechanisms modulating the pathogenesis of AKI still remain largely undetermined. MicroRNAs (miRNAs), small non-coding RNA molecules, play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expression. MicroRNA-21 (miR-21) is a recently identified, typical miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fibrotic signaling pathways in AKI. As a result, miR-21 is now considered a novel biomarker when diagnosing and treating AKI. This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Biomarcadores / Apoptose / MicroRNAs / Diagnóstico / Tratamento Farmacológico / Injúria Renal Aguda / Terapia de Alvo Molecular / Genética / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo de etiologia Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Biomarcadores / Apoptose / MicroRNAs / Diagnóstico / Tratamento Farmacológico / Injúria Renal Aguda / Terapia de Alvo Molecular / Genética / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo de etiologia Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2013 Tipo de documento: Artigo