DNA methylome: Unveiling your biological age
Protein & Cell
;
(12): 723-725, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-757555
ABSTRACT
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Envelhecimento
/
Sequência de Bases
/
Cromatina
/
Genoma Humano
/
Análise de Sequência de DNA
/
Metilação de DNA
/
RNA não Traduzido
/
Epigênese Genética
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2013
Tipo de documento:
Artigo
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