LSY-2 is essential for maintaining the germ-soma distinction in C. elegans
Protein & Cell
;
(12): 599-609, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-757565
ABSTRACT
The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Animais Geneticamente Modificados
/
Caenorhabditis elegans
/
Adenosina Trifosfatases
/
Técnica Indireta de Fluorescência para Anticorpo
/
Genes Essenciais
/
Perfilação da Expressão Gênica
/
Proteínas de Caenorhabditis elegans
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Interferência de RNA
/
Proteínas de Fluorescência Verde
Limite:
Animais
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2015
Tipo de documento:
Artigo
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