Three-dimensional regulation of transcription
Protein & Cell
;
(12): 241-253, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-757601
ABSTRACT
Cells can adapt to environment and development by reconstructing their transcriptional networks to regulate diverse cellular processes without altering the underlying DNA sequences. These alterations, namely epigenetic changes, occur during cell division, differentiation and cell death. Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and non-coding RNAs (ncRNAs). Here, we highlight recent efforts on how the two latter epigenetic factors participate in the sophisticated transcriptional process and describe emerging techniques which permit us to uncover and gain insights into the fascinating genomic regulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transcrição Gênica
/
Cromatina
/
Histonas
/
Diferenciação Celular
/
Divisão Celular
/
Química
/
Processamento de Proteína Pós-Traducional
/
Morte Celular
/
Metilação de DNA
/
RNA não Traduzido
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2015
Tipo de documento:
Artigo
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