Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
Protein & Cell
;
(12): 750-760, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-757654
ABSTRACT
Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as a cofactor and perform key roles in DNA replication, DNA repair, metabolic catalysis, iron regulation and cell cycle progression. Disruption of iron homeostasis always impairs the functions of these iron-requiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals. Organisms have evolved multi-layered mechanisms to regulate iron balance to ensure genome stability and cell development. This review briefly provides current perspectives on iron homeostasis in yeast and mammals, and mainly summarizes the most recent understandings on iron-requiring protein functions involved in DNA stability maintenance and cell cycle control.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ribonucleotídeo Redutases
/
Leveduras
/
DNA
/
Química
/
Reparo do DNA
/
Replicação do DNA
/
Pontos de Checagem do Ciclo Celular
/
Genética
/
Hemeproteínas
/
Ferro
Limite:
Animais
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2014
Tipo de documento:
Artigo
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