Your browser doesn't support javascript.
loading
Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation
Protein & Cell ; (12): 259-265, 2013.
Artigo em Inglês | WPRIM | ID: wpr-757814
ABSTRACT
Pannexin-1 (Panx1) forms nonselective large channel in cell plasma membrane and has been shown to be associated with NLRP3 inflammasome activation, ATP release and phagocytes recruitment. In the current study, by manipulation of Panx1 expression in human myeloid cells and application of Panx1 deficient mice, we failed to find a correlation between Panx1 and NLRP3 inflammasome activation, although an interaction between these two proteins was evident. However, in thioglycollate induced peritonitis, Panx1 deficient mice showed much more phagocytes infiltration. Further analyses showed that mice deficient for Panx1 exhibited enlarged F4/80(low)Gr1(-)Ly6C(-)cell population in the peritonea. Our study thus reveals an important role for Panx1 in regulation of peritoneal cell population and peritonitis development.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Cavidade Peritoneal / Peritonite / Tioglicolatos / Proteínas de Transporte / Linhagem Celular / Conexinas / Biologia Celular / RNA Interferente Pequeno / Interferência de RNA Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Cavidade Peritoneal / Peritonite / Tioglicolatos / Proteínas de Transporte / Linhagem Celular / Conexinas / Biologia Celular / RNA Interferente Pequeno / Interferência de RNA Limite: Animais / Humanos Idioma: Inglês Revista: Protein & Cell Ano de publicação: 2013 Tipo de documento: Artigo