Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
Protein & Cell
;
(12): 83-85, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-757832
ABSTRACT
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicina Regenerativa
/
Reprogramação Celular
/
Células-Tronco Pluripotentes Induzidas
/
Variações do Número de Cópias de DNA
/
Metabolismo
/
Mosaicismo
Limite:
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2013
Tipo de documento:
Artigo
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