A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins
Protein & Cell
;
(12): 893-902, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-757847
ABSTRACT
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Vírus de RNA
/
Química
/
Capsídeo
/
Orthobunyavirus
/
Proteínas do Nucleocapsídeo
/
Vírus Lassa
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2012
Tipo de documento:
Artigo
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