The Elevated Expression of the High Mobility Group-I(Y) Proteins in Thyroid Cancer using Semi-Quantitation RT-PCR
Journal of the Korean Surgical Society
;
: 23-27, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-75849
ABSTRACT
High Mobility Group I(HMG-I) proteins are nuclear proteins that are required for induction of the human IFN-beta gene by virus and for the regulation of the tumor necrosis-beta factor and rRNA genes. Proteins I and Y result from alternative splicing of a single functional gene named HMGI(Y). In several studies, elevated expressions of the HMGI proteins (HMGI, HMGY, and HMGI-C) have been used as markers in thyroid cancer, but not in adenomas, goiters, and normal thyroid tissues and cells. Here, we try to demonstrate the elevated expression of the HMGI(Y) proteins in thyroid carcinomas by using semi-quantified RT-PCR (Reverse Transcription and Polymerase Chain Reaction). In cases of thyroid carcinomas 4 of 5(80%) were positive, in 10 cases of adenomas, goiters, and normal thyroid tissues, 1(10%) was positive. These results suggest that the semi-quantified RT-PCR is useful preoperative diagnostic tool for differentiating thyroid tumors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glândula Tireoide
/
Neoplasias da Glândula Tireoide
/
Proteínas Nucleares
/
Adenoma
/
Processamento Alternativo
/
Genes de RNAr
/
Proteína HMGA1a
/
Bócio
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
1998
Tipo de documento:
Artigo
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