Non-invasive quantification of hepatic fat content in healthy dogs by using proton magnetic resonance spectroscopy and dual gradient echo magnetic resonance imaging
Journal of Veterinary Science
;
: 570-576, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-758825
ABSTRACT
The objective of the present study was to describe two non-invasive methods for fat quantification in normal canine liver by using magnetic resonance imaging (MRI) and spectroscopy. Eleven adult beagle dogs were anesthetized and underwent magnetic resonance examination of the cranial abdomen by performing morphologic, modified Dixon (mDixon) dual gradient echo sequence, and proton magnetic resonance spectroscopy (¹H MRS) imaging. In addition, ultrasonographic liver examination was performed, fine-needle liver aspirates and liver biopsies were obtained, and hepatic triglyceride content was assayed. Ultrasonographic, cytologic, and histologic examination results were unremarkable in all cases. The median hepatic fat fraction calculated was 2.1% (range, 1.3%–5.5%) using mDixon, 0.3% (range, 0.1%–1.0%) using ¹H MRS, and 1.6% (range 1.0%–2.5%) based on triglyceride content. The hepatic fat fractions calculated using mDixon and ¹H MRS imaging were highly correlated to that based on triglyceride content. A weak correlation between mDixon and ¹H MRS imaging was detected. The results show that hepatic fat content can be estimated using non-invasive techniques (mDixon or ¹H MRS) in healthy dogs. Further studies are warranted to evaluate the use of these techniques in dogs with varying hepatic fat content and different hepatic disorders.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prótons
/
Análise Espectral
/
Triglicerídeos
/
Biópsia
/
Imageamento por Ressonância Magnética
/
Abdome
/
Espectroscopia de Prótons por Ressonância Magnética
/
Fígado
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS