Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
Kidney Research and Clinical Practice
;
: 196-204, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-758990
ABSTRACT
BACKGROUND:
Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not been confirmed on a large-scale in the general population. Therefore, we aimed to identify the relationship between hydration status and kidney function.METHODS:
We reviewed the data of 28,342 adults who participated in the Korea National Health and Nutrition Examination Surveys. Urine specific gravity unit (SGU) was the primary variable that indicated hydration status, and the estimated glomerular filtration rate (eGFR) was used as the primary outcome.RESULTS:
Multivariate linear regression analysis showed urine SGU was positively associated with eGFR, which was J-shaped in the multivariate generalized additive model plot. In the penalized spline curve analysis, the odds ratio for high eGFR was steadily increased. Although increased urine SGU was associated with decreased blood pressure and pulse rate, it had no effect on increased fasting glucose and total cholesterol, suggesting conflicting cardio-metabolic dehydration effects.CONCLUSION:
Dehydration, presumably sub-morbid in an ambulatory community-dwelling general population, is associated with higher kidney function. The clinical significance of sub-morbid dehydration-associated glomerular hyperfiltration needs further investigation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Perfusão
/
Gravidade Específica
/
Pressão Sanguínea
/
Modelos Lineares
/
Razão de Chances
/
Colesterol
/
Jejum
/
Desidratação
/
Insuficiência Renal Crônica
/
Taxa de Filtração Glomerular
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Animais
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2019
Tipo de documento:
Artigo
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