Efficacy of JOINS on Cartilage Protection in Knee Osteoarthritis: Prospective Randomized Controlled Trial
The Journal of Korean Knee Society
;
: 217-224, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-759277
ABSTRACT
PURPOSE:
In this study, we compared the clinical efficacy of JOINS (SKI306X, SK Chemicals) with placebo on cartilage protection using magnetic resonance imaging (MRI). MATERIALS ANDMETHODS:
Sixty-nine patients were randomized to the JOINS group (200 mg, three times daily for 1 year; n=33) or the placebo group (n=36). Changes in cartilage volume and thickness were measured using MRI. Changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index, subchondral bone marrow abnormality scores, and clinical scores including knee pain visual analog scale (VAS) score and Korean Western Ontario and McMaster Universities Osteoarthritis Index (K-WOMAC) were also evaluated.RESULTS:
Changes in cartilage thickness and volume and subarticular bone marrow abnormality scores were not different between groups. Changes in the dGEMRIC index in the lateral tibial plateau were greater in the JOINS group than in the placebo group (19.64±114.33 msec vs. −57.77±123.30 msec; p=0.011). Significantly greater changes in VAS were observed in the JOINS group than in the placebo group (−26.00±12.25 vs. −12.47±21.54; p=0.002) and K-WOMAC (−15.42 ± 7.73 vs. −8.15±13.71; p=0.003).CONCLUSIONS:
Compared with placebo, JOINS had superior clinical efficacy in regard to cartilage protection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ontário
/
Osteoartrite
/
Medula Óssea
/
Imageamento por Ressonância Magnética
/
Cartilagem
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Osteoartrite do Joelho
/
Escala Visual Analógica
/
Joelho
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Humanos
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
The Journal of Korean Knee Society
Ano de publicação:
2017
Tipo de documento:
Artigo
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