Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits
The Journal of Korean Knee Society
;
: 44-53, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-759357
ABSTRACT
PURPOSE:
Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intra-articular injection of growth hormone (GH) in OA-induced rabbit knees compared to hyaluronic acid (HA) and placebo. MATERIALS ANDMETHODS:
A total of 21 male, skeletally mature, New Zealand rabbits received an intra-articular type II collagenase injection for OA induction. Two weeks later, the rabbits were randomized into three groups based on the weekly intra-articular injection to be received GH, HA, and saline. Injections were done for three consecutive weeks. Evaluation was done at 8 weeks after treatment, clinically using the lameness period, macroscopically using the Yoshimi score and microscopically using the Mankin score.RESULTS:
The shortest period of lameness was found in the GH group (15.9±2.12 days), compared to the HA group (19.4±1.72 days) and placebo group (25.0±2.94 days). There was a statistically significant difference in macroscopic scoring between groups (p=0.001) in favor of the GH group. There was also significant difference in the microscopic score between groups (p=0.001) also in favor of the GH group.CONCLUSIONS:
Intra-articular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoartrite
/
Hormônio do Crescimento
/
Colagenases
/
Hormônio do Crescimento Humano
/
Ácido Hialurônico
/
Injeções Intra-Articulares
/
Joelho
/
Nova Zelândia
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
País/Região como assunto:
Oceania
Idioma:
Inglês
Revista:
The Journal of Korean Knee Society
Ano de publicação:
2019
Tipo de documento:
Artigo
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