Understanding Vulnerable Plaques: Current Status and Future Directions
Korean Circulation Journal
;
: 1115-1122, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-759428
ABSTRACT
The main cause of acute myocardial infarction is plaque rupture accompanied by superimposed coronary thrombosis. Thin-cap fibroatheromas (TCFAs) have been suggested as a type of lesion with a vulnerability that can cause plaque rupture. However, not only the existence of a TCFA but also the fine and complex interactions of other anatomical and hemodynamic factors, such as microcalcification in the fibrous cap, cholesterol crystal-induced inflammasome activation, the apoptosis of intraplaque macrophages, and endothelial shear stress distribution should precede a clinical event caused by plaque rupture. Recent studies are being conducted to identify these mechanisms through molecular imaging and hemodynamic assessment using computational fluid dynamics, which will result in better clinical results through selective coronary interventions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ruptura
/
Doença da Artéria Coronariana
/
Trombose Coronária
/
Colesterol
/
Apoptose
/
Imagem Molecular
/
Placa Aterosclerótica
/
Inflamassomos
/
Hidrodinâmica
/
Hemodinâmica
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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