Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants / 소아과
Korean Journal of Pediatrics
;
: 166-172, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-760203
ABSTRACT
PURPOSE:
This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs <1,500 g) and to determine the association between vitamin D level and respiratory morbidity.METHODS:
A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first day of life. Patients who were transferred to other hospitals (n=19), died before 36 weeks of gestational age (n=18), or whose blood samples were not collected immediately after birth (n=5) were excluded. Finally, 188 patients were enrolled. VLBWIs with different vitamin D levels were compared with respect to demographic features, maternal diseases, respiratory morbidities, and other neonatal diseases.RESULTS:
The mean serum vitamin D level, as measured by 25-hydroxyvitamin D (25(OH)D), was 13.4±9.3 ng/mL. The incidence of vitamin D deficiency (<20 ng/mL) was 79.8%, and 44.1% of preterm infants had severe vitamin D deficiency (<10 ng/mL). Logistic analysis shows that a low serum 25(OH)D level (<20 ng/mL) was a risk factor for respiratory distress syndrome (odds ratio [OR], 4.32; P=0.010) and bronchopulmonary dysplasia (OR, 4.11; P=0.035).CONCLUSION:
The results showed that 79.8% of preterm infants in this study had vitamin D deficiency at birth. Low vitamin D status was associated with respiratory morbidity, but the exact mechanism was unknown. Additional studies on the association between vitamin D level and neonatal morbidity are required.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Vitaminas
/
Displasia Broncopulmonar
/
Recém-Nascido Prematuro
/
Incidência
/
Estudos Retrospectivos
/
Fatores de Risco
/
Idade Gestacional
/
Recém-Nascido de muito Baixo Peso
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Recém-Nascido
Idioma:
Inglês
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2019
Tipo de documento:
Artigo
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