Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine / 소아과
Korean Journal of Pediatrics
;
: 312-316, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-760226
ABSTRACT
PURPOSE:
The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the rate and types of the hematologic side effects of OXC.METHODS:
The medical records of 184 patients diagnosed with epilepsy or movement disorder and on OXC monotherapy, at the Department of Pediatrics of Inje University Sanggye Paik Hospital from July 2001 to July 2018, were retrospectively reviewed.RESULTS:
Of the 184 patients, 10 (5.4%) developed leukopenia in addition to pancytopenia and 2 (1.0%) developed pancytopenia. Leukopenia developed in 11 days to 14 years after OXC administration and was more frequent in males than in females (male vs. female, 9 vs. 1; Fisher exact test, P0.05, t-test).CONCLUSION:
OXC-induced leukopenia is not rare and may result in pancytopenia. Patients being treated with OXC should be regularly monitored for abnormal complete blood count profiles.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancitopenia
/
Pediatria
/
Contagem de Células Sanguíneas
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Epilepsia
/
Exantema
/
Perda de Seguimento
/
Hiponatremia
/
Leucopenia
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2019
Tipo de documento:
Artigo
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