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Usefulness of Chromosomal Microarray in Hematologic Malignancies: A Case of Aggressive NK-cell Leukemia with 1q Abnormality
Laboratory Medicine Online ; : 189-193, 2019.
Artigo em Coreano | WPRIM | ID: wpr-760494
ABSTRACT
A variety of clonal cytogenetic abnormalities have been reported in aggressive natural killer (NK)-cell lymphoma and leukemia. Recent chromosomal microarray studies have shown both gain and loss of 1q and loss of 7p as recurrent abnormalities in aggressive NK-cell leukemia. Here, we report a case of aggressive NK-cell leukemia with complex chromosomal gains and losses, as confirmed by chromosomal microarray analysis. The patient showed an aggressive clinical course, which was complicated by hemophagocytic lymphohistiocytosis. Conventional cytogenetic analysis revealed trisomy 3 and 1q gain only. However, chromosomal microarray analysis detected an additional gain of 1q21.1–q24.2 and a loss of 1q24.2–q31.3. These abnormal lesions might play a role in the pathogenesis of aggressive NK-cell leukemia by inactivating tumor suppressor genes or by activating oncogenes. These results suggest that chromosomal microarray analysis may be used to provide further genetic information for patients with hematological malignancies, including aggressive NK-cell leukemia.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oncogenes / Trissomia / Leucemia / Genes Supressores de Tumor / Aberrações Cromossômicas / Neoplasias Hematológicas / Análise Citogenética / Análise em Microsséries / Linfo-Histiocitose Hemofagocítica / Linfoma Limite: Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oncogenes / Trissomia / Leucemia / Genes Supressores de Tumor / Aberrações Cromossômicas / Neoplasias Hematológicas / Análise Citogenética / Análise em Microsséries / Linfo-Histiocitose Hemofagocítica / Linfoma Limite: Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2019 Tipo de documento: Artigo