The Association among Serum Leptin System, Bone Biochemical Markers and Bone Mineral Density Before and After Hormone Therapy / 대한골다공증학회지
Journal of Korean Society of Osteoporosis
;
: 9-18, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-760804
ABSTRACT
OBJECTIVES:
To investigate the relationships between serum leptin, soluble leptin receptor (sLR) and bone mineral density (BMD) and bone biochemical markers and to evaluate association among these factors after hormone therapy (HT) in postmenopausal Korean women.METHODS:
Serum leptin, sLR, biochemical markers, osteoprotegerin (OPG) and soluble receptor activator of NF-kB ligand (sRANKL) were measured by enzyme linked immunosorbent assay in 159 postmenopausal Korean women. The BMD at the lumbar spine (LS) and femoral neck (FN) was determined by dual energy X-ray absorptiometry, and changes of these factors were also measured in 70 postmenopausal women receiving HT.RESULTS:
After adjustment for age and year since menopause, body mass index (BMI) was found to be significantly correlated with leptin (r=0.42, P25 kg/m2) were significantly higher than those in women with normal weight, whereas sLR levels were lower in the former women than in the latter women. After HT, serum leptin levels (P<0.005) and FLI (P<0.05) decreased significantly and decreased serum sLR levels (P<0.05) was found only in obese women. The percent changes in BMD at FN after HT were negatively correlated with the changes of sLR after HT.CONCLUSIONS:
Circulating leptin system is not associated with BMD but BMI. Leptin and FLI decrease after HT and the changes of sLR reflects changes in BMD at FN after HT.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Coluna Vertebral
/
Menopausa
/
Ensaio de Imunoadsorção Enzimática
/
Biomarcadores
/
Absorciometria de Fóton
/
Índice de Massa Corporal
/
Densidade Óssea
/
NF-kappa B
/
Terapia de Reposição Hormonal
/
Leptina
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Society of Osteoporosis
Ano de publicação:
2013
Tipo de documento:
Artigo
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