Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population
Psychiatry Investigation
;
: 379-385, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-760935
ABSTRACT
OBJECTIVE:
To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population.METHODS:
We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population.RESULTS:
The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05).CONCLUSION:
Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno Autístico
/
Encéfalo
/
Estudos de Casos e Controles
/
Córtex Pré-Frontal
/
Ácido Glutâmico
/
Povo Asiático
/
Alelos
/
Receptores Ionotrópicos de Glutamato
/
Conjunto de Dados
/
Transtorno do Espectro Autista
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2019
Tipo de documento:
Artigo
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