Angiotensin II type 1 receptor antibodies in kidney transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 6-12, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-761495
ABSTRACT
Angiotensin II type 1 receptor (AT1R) antibodies directly injure endothelial and vascular smooth muscle cells by activating transcription factors associated with proinflammatory responses. Previous studies have shown that AT1R antibodies are associated with allograft rejection and decreased graft survival in kidney transplantation. Development of enzyme-linked immunosorbent assay has facilitated semiquantitative detection of AT1R antibodies. Assessing AT1R antibodies along with donor specific human leukocyte antigen antibodies may have potential to identify patients with possible risk for allograft injury and improve overall outcomes. In this review, we summarize recent clinical studies about AT1R antibodies in kidney transplantation and provide perspectives for future research area.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doadores de Tecidos
/
Transplante
/
Angiotensina II
/
Angiotensinas
/
Ensaio de Imunoadsorção Enzimática
/
Transplante de Rim
/
Receptor Tipo 1 de Angiotensina
/
Fatores Ativadores da Transcrição
/
Aloenxertos
/
Sobrevivência de Enxerto
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
The Journal of the Korean Society for Transplantation
Ano de publicação:
2019
Tipo de documento:
Artigo
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