Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models
The Korean Journal of Physiology and Pharmacology
; : 329-334, 2019.
Article
em En
| WPRIM
| ID: wpr-761803
Biblioteca responsável:
WPRO
ABSTRACT
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Ratos Endogâmicos SHR
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Glicemia
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Ratos Sprague-Dawley
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Modelos Animais
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Hemodinâmica
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Hipertensão
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Hipertrofia
Limite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2019
Tipo de documento:
Article