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Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
The Korean Journal of Physiology and Pharmacology ; : 295-303, 2019.
Artigo em Inglês | WPRIM | ID: wpr-761807
ABSTRACT
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted druginduced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http//ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Relaxamento / Pressão Sanguínea / Técnicas In Vitro / Simulação por Computador / Medicina Clínica / Medição de Risco / Avaliação Pré-Clínica de Medicamentos / Eletrocardiografia / Eletrofisiologia Cardíaca / Descoberta de Drogas Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Relaxamento / Pressão Sanguínea / Técnicas In Vitro / Simulação por Computador / Medicina Clínica / Medição de Risco / Avaliação Pré-Clínica de Medicamentos / Eletrocardiografia / Eletrofisiologia Cardíaca / Descoberta de Drogas Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2019 Tipo de documento: Artigo