State-of-the-Art Strategies for the Vascularization of Three-Dimensional Engineered Organs
Vascular Specialist International
;
: 77-89, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-762016
ABSTRACT
Engineering three-dimensional (3D) implantable tissue constructs is a promising strategy for replacing damaged or diseased tissues and organs with functional replacements. However, the efficient vascularization of new 3D organs is a major scientific and technical challenge since large tissue constructs or organs require a constant blood supply to survive in vivo. Current approaches to solving this problem generally fall into the following three major categories (a) cell-based, (b) angiogenic factor-based, and (c) scaffold-based. In this review, we summarize state-of-the-art technologies that are used to develop complex, stable, and functional vasculature for engineered 3D tissue constructs and organs; additionally, we have suggested directions for future research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Alicerces Teciduais
/
Bioengenharia
Idioma:
Inglês
Revista:
Vascular Specialist International
Ano de publicação:
2019
Tipo de documento:
Artigo
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