Efficacy and Safety of Alitretinoin Therapy in Korean Elderly Patients with Chronic Hand Eczema: A Retrospective Single Center Study
Annals of Dermatology
; : 595-600, 2019.
Article
em En
| WPRIM
| ID: wpr-762398
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that alitretinoin is an effective and well-tolerated treatment for CHE. However, there is a relative lack of data on the effectiveness of alitretinoin in elderly patients. OBJECTIVE: The aim of this study was to investigate the efficacy and safety of oral alitretinoin in elderly patients with moderate to severe CHE in Korea. METHODS: We retrospectively investigated 46 CHE patients who were treated with either 10 mg or 30 mg of alitretinoin between June of 2016 and July of 2018. The physician's global assessment (PGA) was used to evaluate treatment efficacy. All adverse events were retrospectively evaluated with respect to laboratory testing, including complete blood cell count, fasting blood chemistry, lipid profile, and liver and thyroid function tests. RESULTS: The mean patient age in this study was 71.0±5.1 years. The treatment period was over eight weeks. A total of 38 of 46 patients (82.6%) exhibited clinical improvement with PGA ratings of ‘clear’ or ‘almost clear.’ There were 13 patients (28.3%) who experienced an adverse effect, with the most common being headache (13.0%) and gastrointestinal symptoms (8.7%) followed by xerosis (6.5%). A total of 13 patients developed or exhibited worsening hypertriglyceridemia (28.3%). CONCLUSION: Alitretinoin can be considered a safe and effective treatment option in elderly patients with moderate to severe CHE.
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Assunto principal:
Testes de Função Tireóidea
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Contagem de Células Sanguíneas
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Hipertrigliceridemia
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Química
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Estudos Retrospectivos
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Jejum
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Resultado do Tratamento
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Eczema
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Mãos
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Cefaleia
Tipo de estudo:
Observational_studies
Limite:
Aged
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Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Annals of Dermatology
Ano de publicação:
2019
Tipo de documento:
Article